Reactivity of cloned and expressed UGTs with tertiary amines
| Cloned/Expressed UGT | Tertiary Amines | Reference |
|---|---|---|
| Rabbit | ||
| UGT1A4 | Imipramine | (Brucket al., 1997) |
| UGT1A6 | None | (Bruck et al., 1997) |
| UGT1A7 | Imipramine | (Bruck et al., 1997) |
| Human | ||
| UGT2B4 | None | (Jin et al., 1993) |
| UGT2B7 | None | (Ritter et al., 1990) |
| UGT2B10 | None | (Jin et al., 1993) |
| UGT2B15 | None | (Green et al., 1994) |
| UGT1A1 | None | (King et al., 1996) |
| UGT1A3 | Cyproheptadine, amitriptyline, clozapine | (Green et al., 1998) |
| UGT1A4 | Tricyclic antidepressants (e.g. imipramine, amitryptyline, doxepin) | (Green et al., 1995; Green and Tephly, 1996) |
| Antihistaminics (e.g. tripelennamine, cyclizine, cyproheptadine, diphenhydramine) | ||
| Antipsychotic agents (e.g. chlorpromazine, clozapine, triflupromazine, trifluoperazine) | ||
| UGT1A6 | None | (Ebneret al., 1993) |
| UGT1A9 | None | (Ebner et al., 1993) |