Apparent Michaelis-Menten kinetic parameters for human liver microsomes, CYP1A2 and 2C19 catalyzed mono-O-demethylation of methoxychlor
| Methoxychlor monoO-demethylation | |
|---|---|
| CYP2C19 | |
| V max(min−1) | 26.8 ± 1.8 |
| K M (μM) | 0.43 ± 0.08 |
| V max/K M (min−1μM−1) | 62.3 |
| CYP1A2 | |
| V max (min−1) | 12.4 ± 2.13 |
| K M (μM) | 0.51 ± 0.23 |
| V max/K M (min−1μM−1) | 24.3 |
| Human liver microsomes | |
| V max1 (pmol/min/mg) | 71 ± 72 |
| K M1 (μM) | 0.35 ± 0.47 |
| V max2 (pmol/min/mg) | 576 ± 315 |
| K M2 (μM) | 12 ± 17 |