Pharmacokinetic parameter estimates and mean standardized pharmacokinetic parameter estimates following oral administration of 8 mg of ondansetron (Ond) and 1 mg of granisetron (Gran)
| Ond | Gran1-a | Ond | Gran1-a | Ond | Gran1-a | |
|---|---|---|---|---|---|---|
| AUC∞ | (ng · h−1 · ml−1) | AUClast | (ng · h−1 · ml−1) | Cmax | (ng/ml) | |
| Mean | 226 | 37.1 | 210 | 32.8 | 31 | 3.8 |
| Minimum | 62 | 1.9 | 54 | 1.4 | 16 | 0.6 |
| Maximum | 445 | 77.3 | 410 | 66.8 | 48 | 6.4 |
| Standardized mean | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| Standardized minimum | 0.27 | 0.07 | 0.26 | 0.06 | 0.51 | 0.30 |
| Standardized maximum | 1.97 | 2.09 | 1.96 | 2.04 | 1.53 | 1.70 |
| S.D. | 0.45 | 0.82 | 0.45 | 0.81 | 0.29 | 0.55 |
| CV (%) | 44.5 | 82.0 | 45.4 | 81.0 | 29.1 | 54.6 |
| Ratio of variance | 3.39 | 3.19 | 3.52 | |||
| 95% confidence interval | 1.55, 7.42 | 1.50, 6.78 | 1.52 8.15 | |||
| p | 0.0032 | 0.0037 | 0.0042 | |||
↵1-a Granisetron data exclude one subject in whom all concentrations below the LOQ.