Plasma protein binding and uptake into liver of inhibitors
| Drug | KB,app3-a | fP | KBf,app3-b | KBf,real3-c |
|---|---|---|---|---|
| ITZ | 20.9 ± 4.69 | 0.00343-d | 6100 | 6100 |
| KTZ | 4.36 ± 0.87 | 0.00953-d | 460 | 460 |
| VER | 7.67 ± 1.96 | 0.063 | 120 | 600 |
| CAM | 23.3 ± 7.82 | 0.69 | 34 | 36 |
| DLZ | 2.57 ± 0.95 | 0.16 | 16 | 73 |
| ENX | 5.41 ± 0.34 | 0.67 | 8.1 | 9.3 |
| CPFX | 4.88 ± 0.76 | 0.65 | 7.5 | 11 |
| CIM | 3.92 ± 0.68 | 0.803-e | 4.9 | 4.9 |
| NIZ | 2.84 ± 0.85 | 0.963-e | 3.0 | 3.0 |
Values are means ± S.D.
↵3-a Calculated from the apparent KP values and CB/CP ratios.
↵3-b Calculated according to eq. 8.
↵3-c Calculated according to eqs. 7 and 8.
↵3-d Cited from our article concerning the interaction between azole antifungal agents and MDZ (Yamano et al., 1999).
↵3-e Cited from our article concerning the interaction between histamine H2 receptor antagonists and MDZ (Takedomi et al., 1998).