Parameter | Rat | BDC Rat | Dog | Mouse | Monkey |
---|---|---|---|---|---|
i.v. C max(ng/ml)2-a | 1780 ± 585 | 1180, 1310 | 582 ± 87 | 880 ± 265 | 1863 ± 80 |
T 1/2α(min) | 24.1 ± 19.4 | 13.6, 16.2 | 11.2 ± 3.6 | 1.87 ± 0.78 | 9.65 ± 3.34 |
T 1/2β(min) | 192 ± 79 | 82.2, 103 | 559 ± 110 | 26.3 ± 7.8 | 554 ± 779 |
MRT (min)2-a | 200 ± 50 | 94.6, 63.0 | 396 ± 122 | 28.0 ± 15.6 | 241 ± 338 |
CL (kg · ml/min)2-a | 4.05 ± 2.00 | 8.19, 11.2 | 15.2 ± 2.3 | 75.3 ± 19.2 | 13.2 ± 2.0 |
VdSS (ml/kg)2-a | 807 ± 477 | 774, 708 | 6030 ± 2300 | 2040 ± 1055 | 2742 ± 3605 |
k a (min−1)2-a | 0.051 ± 0.040 | 0.55, 0.13 | 0.71 ± 0.08 | 0.35 ± 0.33 | 0.043 ± 0.014 |
Oral T max(min) | 57.5 ± 38.3 | 10.5, 17.1 | 9.90 ± 0.64 | 12.9 ± 11.7 | 32.7 ± 6.2 |
Oral C max(ng/ml)2-a | 2980 ± 700 | 1190, 1080 | 265 ± 45 | 503 ± 124 | 662 ± 282 |
Oral F (%)2-a | 118 ± 36 | 122, 140 | 43.5 ± 11.4 | 68.6 ± 32.0 | 24.0 ± 6.3 |
Data are presented as means ± S.D.
↵2-a Parameter significantly different across species, one-way ANOVA.