Urinary excretion pattern of antipyrine metabolites in rats
| 1-aRatio of Integral Intensity | ||||||||
|---|---|---|---|---|---|---|---|---|
| HMA | HMA-G | NORA-S | NORA-G | OHA-G | OHA-S | DOHA-S | Antipyrine | |
| Normal rats (five rats) | 12.2 ± 0.69 | 5.2 ± 0.73 | 11.4 ± 0.91 | 1.5 ± 0.09 | 11.2 ± 1.00 | 10.6 ± 0.91 | 6.0 ± 0.62 | 2.5 ± 0.38 |
| 3-MC treated rats (four rats) | 1.1 ± 0.46** | 1.0 ± 0.33** | 12.5 ± 1.50 | 6.1 ± 0.66** | 19.1 ± 2.61* | 17.4 ± 1.77* | 5.1 ± 0.49 | |
↵1-a Values listed are means ± S.E. Statistically significant differences (by t test) are identified by *P < .05 and **P < .01. The integral intensity ratios of the metabolites to the I.S. were calculated based on the 13C NMR spectra, and then corrected for the degree of concentration and the total volume of the urine sample.