Dosage of racemic warfarin (mg/day) | 3.3 ± 1.3 | 1.4 ± 0.9**
|
Anticoagulant response |
INR | 1.5 ± 0.4 | 2.3 ± 0.6** |
Dose-adjusted INR (mg−1) | 0.52 ± 0.16 | 1.7 ± 1.0** |
Cp
(μg/ml) |
(S)-warfarin | 0.21 ± 0.07 | 0.29 ± 0.121-150
|
(R)-warfarin | 0.56 ± 0.21 | 0.17 ± 0.07**
|
(S/R)-warfarin | 0.77 ± 0.27 | 0.45 ± 0.19**
|
(S)/(R) ratio | 0.40 ± 0.11 | 1.71 ± 0.29** |
f
u (%) |
(S)-warfarin | 0.85 ± 0.14 | 1.76 ± 0.56**
|
(R)-warfarin | 0.87 ± 0.16 | 1.64 ± 0.37**
|
C
u (ng/ml) |
(S)-warfarin | 1.82 ± 0.69 | 4.77 ± 1.82**
|
(R)-warfarin | 4.77 ± 1.84 | 2.66 ± 0.87**
|
(S/R)-warfarin | 6.59 ± 2.34 | 7.43 ± 2.53 |
(S)/(R) ratio | 0.40 ± 0.13 | 1.81 ± 0.42**
|