Table 1

Oral doses of racemic warfarin, fu, Cp, and Cuvalues of warfarin enantiomers and anticoagulant responses in patients given warfarin alone (Control) and those given warfarin and bucolome (With Bucolome)

Control (n = 34)With Bucolome (n= 21)1-a
Dosage of racemic warfarin (mg/day)3.3  ± 1.31.4  ± 0.9**
Anticoagulant response
 INR1.5  ± 0.42.3  ± 0.6**
 Dose-adjusted INR (mg−1)0.52  ± 0.161.7  ± 1.0**
Cp (μg/ml)
 (S)-warfarin0.21  ± 0.070.29  ± 0.121-150
 (R)-warfarin0.56  ± 0.210.17  ± 0.07**
 (S/R)-warfarin0.77  ± 0.270.45  ± 0.19**
 (S)/(R) ratio0.40  ± 0.111.71  ± 0.29**
f u (%)
 (S)-warfarin0.85  ± 0.141.76  ± 0.56**
 (R)-warfarin0.87  ± 0.161.64  ± 0.37**
C u (ng/ml)
 (S)-warfarin1.82  ± 0.694.77  ± 1.82**
 (R)-warfarin4.77  ± 1.842.66  ± 0.87**
 (S/R)-warfarin6.59  ± 2.347.43  ± 2.53
 (S)/(R) ratio0.40  ± 0.131.81  ± 0.42**

  • Data are means ± S.D.

  • ↵1-a Bucolome was given orally at 300 mg once a day.

  • ↵1-150  p < .05 and ** p < .01 as compared with Control group.