Human Sample No. | Total CYP2-a | Individual CYP Enzymes2-b | |||||||
---|---|---|---|---|---|---|---|---|---|
1A2 | 2A6 | 2B6 | 2C | 2D6 | 2E1 | 3A | Sum2-c | ||
nmol/mg protein | % of total CYP | ||||||||
J-1 | 0.11 | 8 | 0.4 | 0.2 | 21 | 0.5 | 9 | 19 | 58 |
J-2 | 0.14 | 11 | 0.3 | 0.1 | 24 | 1 | 4 | 47 | 88 |
J-3 | 0.15 | 2 | 0.3 | nd | 15 | 0.4 | 1 | 25 | 45 |
J-4 | 0.55 | 4 | 0.1 | 5 | 20 | 0.8 | 3 | 45 | 78 |
J-5 | 0.17 | 9 | 0.3 | nd | 34 | 0.9 | 5 | 18 | 67 |
J-6 | 0.19 | 6 | 8 | 0.1 | 35 | 0.8 | 7 | 31 | 88 |
J-7 | 0.33 | 18 | 3 | 2 | 21 | 0.4 | 5 | 35 | 85 |
J-8 | 0.05 | 30 | 1 | 1 | 26 | 2 | 4 | 32 | 95 |
J-9 | 0.48 | 14 | 1 | 0.1 | 20 | 1 | 4 | 26 | 65 |
J-10 | 0.23 | 9 | 14 | 1 | 15 | 1 | 6 | 47 | 92 |
J-19 | 0.09 | 11 | 2 | nd | 10 | 4 | 2 | 27 | 56 |
J-20 | 0.13 | 5 | 0.4 | 0.3 | 32 | 2 | 5 | 50 | 95 |
J-21 | 0.04 | 20 | 2 | 0.1 | 55 | 6 | 5 | 33 | 121 |
J-22 | 0.07 | 4 | 0.3 | nd | 27 | 1 | 3 | 13 | 48 |
J-23 | 0.19 | 9 | 0.5 | nd | 33 | 2 | 9 | 16 | 70 |
J-24 | 0.23 | 7 | 0.1 | nd | 30 | 2 | 9 | 14 | 61 |
Mean | 0.20 | 10 | 2 | 0.6 | 26 | 2 | 5 | 30 | 76 |
± S.D. | 0.15 | 7 | 4 | 1 | 11 | 2 | 2 | 12 | 20 |
C-11 | 0.52 | 7 | 4 | 2 | 16 | 1 | 31 | 17 | 78 |
C-12 | 0.50 | 9 | 4 | 4 | 20 | 1 | 31 | 16 | 87 |
C-13 | 0.55 | 6 | 4 | 9 | 17 | 2 | 4 | 26 | 67 |
C-14 | 0.35 | 13 | 5 | 0.5 | 23 | 2 | 9 | 23 | 76 |
C-15 | 0.28 | 23 | 2 | 0.2 | 25 | 2 | 5 | 20 | 78 |
C-16 | 0.31 | 16 | 4 | 0.2 | 18 | 2 | 5 | 17 | 62 |
C-17 | 0.27 | 16 | 1 | nd | 10 | 3 | 12 | 14 | 56 |
C-18 | 0.35 | 13 | 9 | 1 | 8 | 2 | 6 | 27 | 66 |
Mean | 0.39 | 13 | 4 | 2 | 17 | 2 | 13 | 20 | 71 |
± S.D. | 0.11 | 6 | 2 | 3 | 6 | 0.7 | 12 | 5 | 10 |