Subject, Sex | Age (years) | Weight | 24-h Excretion | |||
---|---|---|---|---|---|---|
(S)-GlucA | (S)-GlucB | (R)-GlucA+ (R)-GlucB | Total glucuronides | |||
kg | % of the dose | |||||
BD, f | 24 | 60 | 0.9 | 14.0 | 3.6 | 18.5 |
HM, f | 26 | 57 | 2.05 | 16.3 | 1.8 | 20.1 |
PI, f | 32 | 63 | 1.1 | 9.7 | 1.7 | 12.5 |
WG, f | 44 | 65 | 2.2 | 17.2 | 3.4 | 22.9 |
3.05∗ | 22.0∗ | 4.8∗ | 29.9∗ | |||
BP, f | 61 | 53 | 1.6 | 12.3 | 1.2 | 15.1 |
MU, m | 28 | 68 | 0.5 | 11.4 | 2.2 | 14.1 |
HJ, m | 32 | 80 | 1.4 | 13.6 | 6.7 | 21.7 |
MK, m | 43 | 80 | 0.8 | 10.3 | 0.7 | 11.8 |
WR, m | 45 | 86 | 1.9 | 16.2 | 3.3 | 21.4 |
ME, m | 58 | 75 | 1.15 | 10.8 | 2.95 | 14.9 |
mean | 39 | 69 | 1.4 | 13.2 | 2.8 | 17.3 |
S.D. | 13 | 11 | 0.6 | 2.7 | 1.7 | 4.1 |
Percentages refer to the dose of 1 mg, not to those of the enantiomers.
∗, values obtained during continuous treatment with 1 mg of ketotifen daily (not included in calculating means).