CYP2B6 and CYP3A diagnostic catalytic activities in human liver microsomes
| Substrates2-a | 7-EFCO-Deethylase | Testosterone 6β-Hydroxylase |
|---|---|---|
| pmol/min/mg protein | ||
| P-450s | CYP2B6 | CYP3A |
| HLS no. | ||
| 2 | 452 | 4890 |
| 9 | 340 | 14740 |
| 18A | 129 | 6570 |
| 25 | 55 | 7950 |
| 27 | 54 | 7120 |
| 28 | 41 | 7200 |
| 35 | 169 | 3180 |
| 36 | 137 | 4280 |
↵2-a Human liver microsomes were assayed for catalytic activities associated with CYP2B6 (7-EFC O-deethylase) and CYP3A enzymes (testosterone 6β-hydroxylase) as described inExperimental Procedures. Data shown are from Code et al. (1997) (7-EFC; Gentest) and Roy et al. (1999) (testosterone; Gentest).