Organ | [14C]PEITC | [14C]PHITC | ||||
---|---|---|---|---|---|---|
Parameter2-a | Estimate | S.E. | Parameter | Estimate | S.E. | |
Nasal mucosa | AUC2-a | 378.50 | 341.42 | AUC | 365.55 | 87.39 |
T1/2a (h) | 0.93 | 1.20 | T1/2a(h) | 3.46 | 1.61 | |
T1/2e(h) | 10.10 | 12.16 | T1/2e (h) | 23.72 | 11.03 | |
Tmax (h) | 3.52 | 0.66 | Tmax(h) | 11.31 | 1.78 | |
Cmax(pmol/mg) | 20.40 | 7.31 | Cmax (pmol/mg) | 7.69 | 0.64 | |
Esophagus | AUC | 140.19 | 111.69 | AUC | 180.49 | 102.07 |
T1/2a (h) | 0.67 | 0.69 | T1/2a(h) | 0.19 | 0.32 | |
T1/2e(h) | 9.72 | 9.89 | T1/2e (h) | 4.84 | 4.00 | |
Tmax (h) | 2.77 | 1.78 | Tmax(h) | 0.91 | 1.04 | |
Cmax(pmol/mg) | 8.20 | 2.14 | Cmax (pmol/mg) | 22.70 | 5.24 | |
Stomach | AUC | 1409.7 | 457.62 | AUC | 1514.76 | 197.74 |
T1/2a (h) | 0.37 | 0.24 | T1/2a(h) | 0.32 | 0.07 | |
T1/2e(h) | 3.57 | 1.93 | T1/2e (h) | 5.50 | 1.04 | |
Tmax (h) | 1.35 | 0.45 | Tmax(h) | 1.40 | 0.18 | |
Cmax(pmol/mg) | 211.19 | 26.44 | Cmax(pmol/mg) | 159.87 | 7.09 | |
Small intestine | AUC | 1691.21 | 292.94 | AUC | 2484.70 | 354.02 |
T1/2a (h) | 1.69 | 0.64 | T1/2a(h) | 1.61 | 0.52 | |
T1/2e(h) | 5.23 | 2.22 | T1/2e (h) | 4.85 | 1.77 | |
Tmax (h) | 4.07 | 0.41 | Tmax(h) | 3.83 | 0.30 | |
Cmax(pmol/mg) | 130.58 | 7.64 | Cmax (pmol/mg) | 205.39 | 9.64 | |
Cecum | AUC | 10422.29 | 44129.90 | AUC | 1833.39 | 519.02 |
T1/2a (h) | 2.52 | 1.07 | T1/2a(h) | 10.99 | 179.48 | |
T1/2e(h) | 465.87 | 2061.42 | T1/2e (h) | 10.42 | 170.02 | |
Tmax (h) | 19.09 | 11.51 | Tmax(h) | 15.43 | 3.01 | |
Cmax(pmol/mg) | 15.07 | 1.78 | Cmax (pmol/mg) | 43.69 | 6.25 | |
Colon | AUC | 361.39 | 47.32 | AUC | 934.68 | 252.00 |
T1/2a (h) | 5.40 | 35.71 | T1/2a(h) | 0.67 | 0.31 | |
T1/2e(h) | 5.81 | 37.92 | T1/2e (h) | 14.06 | 5.98 | |
Tmax (h) | 8.08 | 1.15 | Tmax(h) | 3.08 | 0.83 | |
Cmax(pmol/mg) | 16.43 | 1.22 | Cmax (pmol/mg) | 39.58 | 0.91 | |
Pancreas | AUC | 176.0 | 29.04 | AUC | 1073.6 | 470.23 |
T1/2a (h) | 0.97 | 0.14 | T1/2a(h) | 0.91 | 0.25 | |
T1/2e(h) | 54.96 | 11.78 | T1/2e (h) | 80.51 | 40.99 | |
Tmax (h) | 4.53 | 0.40 | Tmax(h) | 5.97 | 1.09 | |
Cmax(pmol/mg) | 9.73 | 0.39 | Cmax (pmol/mg) | 8.78 | 0.69 | |
Spleen | AUC | 57.71 | 30.55 | AUC | 1033.28 | 342.41 |
T1/2a (h) | 0.33 | 0.37 | T1/2a(h) | 2.28 | 0.46 | |
T1/2e(h) | 3.20 | 2.83 | T1/2e (h) | 111.18 | 44.11 | |
Tmax (h) | 1.20 | 0.71 | Tmax(h) | 13.04 | 1.23 | |
Cmax(pmol/mg) | 9.64 | 2.00 | Cmax (pmol/mg) | 5.94 | 0.26 | |
Heart | AUC | 94.35 | 22.99 | AUC | 409.32 | 98.13 |
T1/2a (h) | 1.48 | 0.61 | T1/2a(h) | 1.55 | 0.30 | |
T1/2e(h) | 7.75 | 3.41 | T1/2e (h) | 59.39 | 18.12 | |
Tmax (h) | 4.36 | 0.74 | Tmax(h) | 8.39 | 0.95 | |
Cmax(pmol/mg) | 5.71 | 0.51 | Cmax (pmol/mg) | 4.33 | 0.25 | |
Brain | AUC | 53.71 | 5.40 | AUC | 116.89 | 19.62 |
T1/2a (h) | 2.07 | 0.41 | T1/2a(h) | 2.29 | 0.61 | |
T1/2e(h) | 12.58 | 2.27 | T1/2e (h) | 26.20 | 7.21 | |
Tmax (h) | 6.46 | 0.57 | Tmax(h) | 8.82 | 1.16 | |
Cmax(pmol/mg) | 2.07 | 0.10 | Cmax(pmol/mg) | 2.45 | 0.18 |
↵2-a Units of AUC are picomoles per milligram × hours.