Effects of aldehyde oxidase (AO) and xantin oxidase (XO) inhibitors on the transformation Lu 29-297 to Lu 35-038 in human liver S-9
| Inhibitor Concentration | Menadion (AO inhibitor) | Quercetin (AO inhibitor) | Allopurinol (XO inhibitor) |
|---|---|---|---|
| % of control | |||
| 0.01 mM | 90.6 ± 9.9 | 6.5 ± 3.9 | 96.3 ± 12.6 |
| 0.1 mM | 48.6 ± 2.2 | 3.0 ± 1.0 | 97.2 ± 4.5 |
| 1.0 mM | 47.9 ± 4.1 | 5-a | 5-a |
↵5-a Not tested because of lower solubility of the compound.