Table 7

Inhibition of Lu 35-026 formation in pooled human liver microsomes by selective P-450 inhibitors

Treatment7-a% of Control7-b
Furafylline—40 μM—1A225
Coumarin—200 μM—2A6/2E167
Sulphaphenazole—40 μM—2C998
Tranylcypramin—10 μM—2C1996
Quinidine—10 μM—2D6100
DDC—100 μM—2E1/2A685
Ketoconazole—5 μM—3A4/5101

  • ↵7-a Incubations were performed in duplicate at Lu 35-038 concentration of 400 μM.

  • ↵7-b Values represent the mean of duplicate measurements as a percentage of duplicate control measurements including solvents (without inhibitors).