Table 1

Excretion of taurine conjugate of R,S-MTPPA in urine and feces for 48 h after oral administration of S-MTPPA or R-MTPPA at a dose of 10 mg/kg to male rats and dogs

SpeciesAdministered CompoundExcretion of Taurine Conjugate (% of dose)
UrineFeces
Dog S-MTPPA10.9  ± 1.913.5  ± 1.0
R-MTPPA13.5  ± 1.813.8  ± 1.6
Rat S-MTPPAND1-a ND
R-MTPPA0.61-b ND
  • Values are the mean ± S.D. of three animals.

  • 1-a ND, not detected.

  • 1-b Value for one animal.