Table 1

Excretion of radioactivity in rats and dogs after a single i.v. (1 mg/kg) dose of [³H]tirofiban

Species	Hours	Urine	Radioactivity Excreted
Species	Hours	Urine	Feces	Bile	Total
			% of Dose
Rat^1-a	0–139	23 ± 2	59 ± 6	-^d	82 ± 7
Rat^b	0–24	23 ± 4	ND	74 ± 6	98 ± 6
Dog^c	0–72	9 ± 1	82 ± 6	-^d	91 ± 6

Rats (240 g) and dogs (8–12 kg) received [³H]tirofiban of specific activity 42.1 and 6.3 μCi/mg, respectively. ND = not determined.
↵1-a N = 6; ^b N = 3;^c N = 4. Values shown are mean ± S.D.^d Not cannulated.