Table 4

Mean concentrations of radioactivity in blood, plasma, and tissues from male rats given [¹⁴C]tirofiban hydrochloride (1 mg/kg i.v.)

Matrix	μg Equivalents [¹⁴C]Tirofiban/g
Matrix	5 min	30 min	2 h	24 h
Adrenals	0.184 ± 0.073	-^4-a	-^4-a	-^4-a
Blood	0.641 ± 0.110	0.059 ± 0.002	0.005 ± 0.000	-^4-a
Bone marrow^4-b	0.264 ± 0.049	0.012 ± 0.011	-^4-a	-^4-a
Brain	0.034 ± 0.007	0.006 ± 0.001	-^4-a	-^4-a
Eyes	0.140 ± 0.039	0.018 ± 0.004	0.003 ± 0.006	-^4-a
Fat (reproductive)	0.090 ± 0.018	0.013 ± 0.004	0.008 ± 0.007	-^4-a
Heart	0.250 ± 0.043	0.022 ± 0.001	0.003 ± 0.000	-^4-a
Kidneys	5.31 ± 1.37	0.382 ± 0.064	0.020 ± 0.000	-^4-a
Large intestine	0.249 ± 0.090	0.033 ± 0.004	0.349 ± 0.417	0.044 ± 0.017
Liver	9.78 ± 0.705	1.36 ± 0.164	0.070 ± 0.003	0.006 ± 0.000
Lungs	0.364 ± 0.087	0.025 ± 0.000	0.005 ± 0.001	-^4-a
Lymph nodes (cervical)	0.346 ± 0.120	0.023 ± 0.002	-^4-a	-^4-a
Lymph nodes (mesenteric)	0.239 ± 0.100	0.024 ± 0.005	0.023 ± 0.009	-^4-a
Muscle (thigh)	0.122 ± 0.017	0.011 ± 0.001	0.003 ± 0.002	-^4-a
Pancreas	0.620 ± 0.385	0.031 ± 0.001	0.005 ± 0.004	-^4-a
Pituitary	0.475 ± 0.155	-^4-a	-^4-a	-^4-a
Plasma	1.25 ± 0.230	0.098 ± 0.003	0.005 ± 0.001	-^4-a
Prostate	0.266 ± 0.032	0.135 ± 0.107	0.131 ± 0.077	-^4-a
Skin (dorsal, shaven)	0.433 ± 0.036	0.036 ± 0.005	0.007 ± 0.012	-^4-a
Small Intestine	1.000 ± 0.162	2.03 ± 0.306	2.00 ± 0.374	0.031 ± 0.009
Spleen	0.145 ± 0.035	0.011 ± 0.001	0.003 ± 0.002	-^4-a
Stomach	0.684 ± 0.241	0.019 ± 0.004	0.008 ± 0.006	0.017 ± 0.015
Testes	0.079 ± 0.011	0.031 ± 0.004	0.004 ± 0.001	-^4-a
Thymus	0.133 ± 0.054	0.012 ± 0.001	0.003 ± 0.002	-^4-a
Thyroid	0.273 ± 0.077	0.012 ± 0.020	-^4-a	-^4-a
Urinary bladder	0.422 ± 0.066	0.705 ± 0.303	0.195 ± 0.163	-^4-a

Values are mean and S.D. (N = 3).
↵4-a Not detectable.
↵4-b From both femurs.