Table 6

Mean (SD) CYP-450 levels in rats and monkeys (N = 3/gender)

Species	Dose	Mean (SD) CYP450 Levels^6-a
	(mg/kg/day)	(nmol/mg protein)
Rat	Control^6-b	0.440 (0.084)
	100	0.444 (0.049)
	300	0.415 (0.108)
	600	0.397 (0.084)
Monkey	Control	0.791 (0.072)
	60	0.977 (0.084)^6-c
	200	0.807 (0.083)
	600	0.688 (0.121)

↵6-a CYP-450 levels were not significant between gender.
↵6-b Control animals were administered sterile water.
↵6-c p < 0.05 compared with control.