Study | Species | Dose | Multiples of Human Exposure |
---|---|---|---|
(mg/kg/day) | |||
12 mo | Rat | 1007-a | 50× |
300 | 155× | ||
600 | 358× | ||
Monkey | 607-a | 10× | |
200 | 24× | ||
600 | 67× | ||
Fertility and reproduction | Rat | 100 | 46× |
3007-a | 135× | ||
600 | 216× | ||
Teratology | Rat | 50 | 24× |
2507-a | 143× | ||
1000 | 399× | ||
Rabbit | 60 | 18× | |
300 | 82× | ||
6007-a | 183× | ||
Maternal-fetal | Rat Fetus | 3007-a | 146× |
Neurotoxicity | Rabbit | 750 | 440× |
15007-a | 1102× | ||
Carcinogenicity | Mouse | 80 | 13× |
4007-b | 39× | ||
2000 | 250× | ||
Rat | 100 | 34× | |
6007-b | 168× | ||
2000 | 732× |