Table 2

Coefficients of regression for formation of Lu 25-109 metabolites at pH 7.4 with form-selective enzyme activities

Form-Selective Activity^2-a	Correlation Coefficient (r²)
Form-Selective Activity^2-a	Lu 31-126^2-b	Lu 29-297^2-b	Lu 25-077^2-b	Lu 32-181^2-b
7-Ethoxyresorufin O-dealkylation (1A2)	0.092	0.191	0.127	0.041
Coumarin 7-hydroxylation (2A6)	0.091	0.553^2-150	0.377^2-150	0.164
Tolbutamide methyl-hydroxylation (2C9)	0.041	0.018	0.001	0.008
S-mephenytoin 4′-hydroxylation (2C19)	0.039	0.277	0.091	0.144
DextromethorphanO-demethylation (2D6)	0.794^2-150	0.220	0.206	0.158
Chlorzoxazone 6-hydroxylation (2E1)	0.209	0.172	0.141	0.182
DextromethorphanN-demethylation (3A4)	0.097	0.489^2-150	0.470^2-150	0.008
Testosterone 6β-hydroxylation (3A4/5)	0.024	0.213	0.173	0.069
Lauric acid 12-hydroxylation (4A9/11)	0.012	0.041	0.001	0.142
N-oxygenation of tertiary amine (FMO3)^2-c	0.044	0.003	0.005	0.021
Methyl toluyl sulfide S-oxygenation (FMO3)^2-d	0.074	0.075	0.020	0.008

↵2-150 P < 0.05.
↵2-a Determined by Xenotech as described in Materials and Methods.
↵2-b Incubations were performed in triplicate at Lu 25-109 concentration of 200 μM.
↵2-c Determined at pH 7.5.
↵2-d Determined at pH 8.5.