Formation rates of Lu 25-109 metabolites by 14 human liver samples at pH 8.5
| Human Liver Sample | Formation Rate | |||
|---|---|---|---|---|
| Lu 31-126 | Lu 29-297 | Lu 25-077 | Lu 32-181 | |
| pmol product/mg/min3-a | ||||
| 2 | 11.6 | 58.7 | 43.1 | 16.0 |
| 5 | 26.5 | 72.6 | 31.5 | 26.5 |
| 7 | 8.3 | 124.2 | 55.7 | 45.1 |
| 11 | 37.6 | 165.9 | 112.1 | 49.6 |
| 12 | 17.7 | 36.5 | 14.9 | 9.7 |
| 13 | 18.5 | 56.1 | 30.7 | 27.3 |
| 14 | 50.9 | 95.9 | 51.3 | 26.5 |
| 15 | 3.9 | 93.5 | 36.1 | 24.0 |
| 16 | 32.5 | 154.3 | 69.2 | 37.9 |
| 17 | 27.8 | 159.4 | 76.1 | 33.4 |
| 18 | 21.5 | 113.2 | 73.0 | 42.7 |
| 19 | 14.3 | 77.7 | 52.4 | 36.6 |
| 20 | 4.6 | 62.0 | 31.9 | 21.2 |
| 21 | 20.1 | 169.0 | 92.4 | 52.4 |
↵3-a Incubations were performed in triplicate at Lu 25-109 concentration of 200 μM.