Table 1

Metabolite profile of 0 to 72 h urine of rats and hamsters following a 30- or 2000-mg/kg oral dose of GEM^1-a

Sex and Dose Level	Overall Recovery in Urine	Chromatographic Peaks^1-b
Sex and Dose Level	Overall Recovery in Urine	A	B	C	L	D	E	F	I	K
Male rat
30 mg/kg	2.639	0.186	0.241	0.149	0.577	ND^1-c	0.059	0.234	1.133	ND
	(29.9)	(2.1)	(2.7)	(1.7)	(6.5)	(ND)	(0.7)	(2.7)	(12.8)	(ND)
2000 mg/kg	1223	239^1-d	151	234	22	78	10	313	187	11
	(53.6)	(10.5)	(6.6)	(10.3)	(1.0)	(3.4)	(0.4)	(13.7)	(8.2)	(0.5)
Female rat
30 mg/kg	1.893	0.054	0.064	0.048	0.236	ND	ND	0.172	1.193	0.087
	(32.6)	(0.9)	(1.1)	(0.8)	(4.1)	(ND)	(ND)	(3.0)	(20.5)	(1.5)
2000 mg/kg	1043	52^1-d	47	36	44	265	ND	225	347	9
	(67.7)	(3.4)	(3.0)	(2.3)	(2.9)	(17.2)	(ND)	(14.6)	(22.5)	(0.6)
Male hamster
30 mg/kg	3.230	0.116	0.411	0.072	0.011	0.255	0.410	1.233	0.506	ND
	(90.2)	(3.2)	(11.5)	(2.0)	(0.3)	(7.1)	(11.5)	(34.4)	(14.1)	(ND)
2000 mg/kg	818	82^1-d	47	41	12	78	70	369	84	6
	(83.0)	(8.3)	(4.8)	(4.2)	(1.2)	(7.9)	(7.1)	(37.5)	(8.5)	(0.6)
Female hamster
30 mg/kg	3.760	0.068	0.331	0.043	0.004	0.427	0.196	0.768	1.713	0.006
	(90.6)	(1.6)	(8.0)	(1.0)	(0.1)	(10.3)	(4.7)	(18.5)	(41.3)	(0.1)
2000 mg/kg	940	82^1-d	33	33	17	129	35	414	140	21
	(87.3)	(7.7)	(3.1)	(3.1)	(1.6)	(12.0)	(3.2)	(38.4)	(13.0)	(1.9)

↵1-a Results are expressed in milligram equivalents and percent dose excreted; percent dose in parentheses.
↵1-b Peaks are listed in order of elution with metabolite A being the most polar. See Figs. 4 and 7 for metabolite structures.
↵1-c Metabolite not detected.
↵1-d Composed of at least two components. Combined results of the two are listed.