Metabolite | % of Sample | |||
---|---|---|---|---|
Plasma Mean S.E. | Brain Mean S.E. | Liver Mean S.E. | Kidney Mean S.E. | |
Donepezil | 31.0 ± 2.89 | 89.8 ± 6.18 | 80.8 ± 1.49 | 71.6 ± 4.15 |
M1 | BQL | BQL | 1.78 ± 0.29 | 0.97 ± 0.24 |
M2 | BQL | BQL | 2.10 ± 0.16 | 1.52 ± 0.15 |
M3 | BQL | BQL | 0.26 ± 0.02 | BQL |
M4 | 3.29 ± 0.83 | BQL | 4.72 ± 0.46 | 8.12 ± 0.85 |
M5 | BQL | BQL | 0.14 ± 0.01 | BQL |
M6 | BQL | BQL | BQL | BQL |
M7 | BQL | BQL | 0.70 ± 0.13 | BQL |
M7 sulfate | BQL | BQL | 0.81 ± 0.14 | BQL |
M8 | BQL | BQL | 0.54 ± 0.24 | BQL |
M9 | BQL | BQL | BQL | BQL |
M10 | BQL | BQL | BQL | BQL |
O-glucuronide | 55.1 ± 5.33 | BQL | 4.17 ± 0.82 | 15.1 ± 4.01 |
UM1 | BQL | BQL | 0.53 ± 0.43 | BQL |
UM2 | BQL | BQL | BQL | BQL |
UM3 | BQL | BQL | 0.38 ± 0.10 | BQL |
Others | 10.7 ± 1.37 | 10.2 ± 6.18 | 2.93 ± 0.25 | 1.95 ± 0.72 |
Mean and S.E. are calculated for four rats at each time point. BQL, <40 dpm/sample; 0.135 ng eq/sample.