Table 1

Effects of PH, QO, and DP on hepatic microsomal CYP activities in rat liver microsomes

TreatmentCYP 1A21-aCYP 2E11-bCYP 3A1-c
nmol/mg/min nmol/mg/min nmol/mg/min
Control0.41  ± 0.0191-d 1.09  ± 0.100.31  ± 0.10
PH0.52  ± 0.0370.80  ± 0.0740.27  ± 0.068
QO0.45  ± 0.0110.74  ± 0.330.24  ± 0.064
DP0.58  ± 0.0781.14  ± 0.120.38  ± 0.047

  • ↵1-a Acetanilide 4-hydroxylase activity.

  • ↵1-b p-Nitrophenol hydroxylase activity.

  • ↵1-c Erythromycin N-demethylase activity.

  • ↵1-d Parameters determined are given as the mean ± S.D. (n = 4).