Correlation of S-mephobarbital N-demethylase activity with CYP isoform-specific activity or immunoreactive CYP2B6 level in 10 human liver microsomes
| CYP | r |
|---|---|
| 1A2 (phenacetin O-deethylase activity) | 0.249 |
| 2A6 (coumarin 7-hydroxylase activity) | 0.799** |
| 2B6 (immunoreactive level) | 0.920*** |
| 2C9 (diclofenac 4′-hydroxylase activity) | 0.152 |
| 2C19 (S-mephenytoin 4′-hydroxylase activity) | 0.6932-150 |
| 2D6 (desipramine 2-hydroxylase activity) | 0.028 |
| 2E1 (chlorzoxazone 6-hydroxylase activity) | 0.299 |
| 3A (testosterone 6β-hydroxylase activity) | 0.547 |
↵2-150 p < .05; ** p < .01; *** p < .001.