Table 1

Pharmacokinetic parameters of lenercept in laboratory animals (mean ± S.D. or range)

Species	Dose(mg/kg)	n	Cl (ml/min/kg)	V_i(ml/kg)	V_ss(ml/kg)	T_1/2 (days)
Rat^1-a	0.2	4	n.d.	42	n.d.	n.d.
	5	4	0.0071	47	90	6.5
Rabbit^1-b	5	3	0.0094–0.010	37 ± 6	51–71	2.6–4.2
Cynomolgus monkey	4–5	4	0.0082 ± 0.0011	40 ± 5	77 ± 14	5.1 ± 0.75
Dog	0.1	2	0.0086–0.0088	42–53	54–101	3.9–6.1

n.d., not determined.
↵1-a Pharmacokinetic parameters calculated from composite plasma levels.
↵1-b One animal excluded from calculation of Cl,V_ss, and T_1/2 due to early onset of immune response.