Table 2

Allometric scaling of lenercept

Pharmacokinetic Parameter	Coefficient a	Allometric Exponent b	Man Predicted	Man Observed^2-b
Cl	−2.10	1.06	0.66 ml/min	0.33 ml/min
V _ss	1.90	0.969	70 ml/kg	70 ml/kg
T _1/2	0.718	−0.0789	3.7 days	7.0 days
T _1/2 ^2-a	0.694	−0.0375	4.2 days	7.0 days

Coefficients a and allometric exponents b of allometric equations as well as predicted and observed pharmacokinetic parameters in man

↵2-a Extrapolation including data in mice taken from Haak Frendscho et al. (1994).
↵2-b Data taken from Kneer et al. (1996).