Table 1

Mean (± S.D.) toxicokinetic parameters of 1-NN in blood after i.p. administration of 100 mg/kg (N = 3) or i.v. administration of 10 mg/kg (N = 3) to male Sprague-Dawley rats

Kinetic Parameter	i.p.	i.v.
	100 mg/kg	10 mg/kg
k _rise (h⁻¹)	1.55 ± 0.30	n/a^1-a
T _1/2,rise (h)	0.46 ± 0.08	n/a
k _term (h⁻¹)	0.21 ± 0.04	0.94 ± 0.22
T _1/2,term (h)	3.40 ± 0.63	0.77 ± 0.21
AUC (mg h/l)	25.93 ± 8.10	3.85 ± 2.21
CL (l/h/kg)	2.59 ± 0.00	3.11 ± 1.36
V _D (l/kg)	n/a	3.17 ± 0.82
V _SS (l/kg)	n/a	2.79 ± 0.55
F	0.67 ± 0.21	n/a
T _max (h)	1.52 ± 0.19	n/a
C _max (μg/ml)	3.94 ± 1.34	n/a

↵1-a n/a, not applicable.