Table 2

The oral clearance of busulfan in relation to disease and age

Disease category	Cl/F	Age Category, years
Disease category	Cl/F	0 to 4	5 to 8	9 to 16
Inherited disorders	ml/min/kg^2-a	7.13 ± 3.35	5.59 ± 2.82	3.05, 3.60^2-b
Malignant	ml/min/kg^2-a	6.41 ± 2.27	4.86 ± 2.47	3.34 ± 0.54
Inherited disorders	ml/min/m²	145 ± 56	141 ± 72	103, 113^2-b
Malignant	ml/min/m²	139 + 51	126 ± 61	109 ± 17

The data are the mean ± S.D. The number of patients with inherited disorders was 25, 6, and 2 for 0- to 4-, 5- to 8-, and 9- to 16-year old children, respectively. The number of patients with malignant diseases was 27, 17, and 24 for 0- to 4-, 5- to 8-, and 9- to 16-year-old children, respectively. Statistical comparisons were made between disease categories within a single age group using the Mann-Whitney U test.

↵2-a Busulfan Cl/F expressed relative to AIBW.
↵2-b The range was reported because there were only two patients.