Recovery of radioactivity 168 h after [14C]1,2-DEB i.v. or oral administration to non bile duct-cannulated male Sprague-Dawley rats1-a
| Treatment | Fractional Excretion | |||||
|---|---|---|---|---|---|---|
| Route of Administration | Dose | Urine | Feces | Total Activity Exhaled | Carcass | Total Recovery |
| mg/kg b.wt. | % of the dose | |||||
| i.v. | 1 | 75.7 ± 2.6 | 15.3 ± 1.7 | 2.97 ± 0.11 | 3.29 ± 0.06 | 97 ± 2 |
| Oral | 1 | 75.5 ± 2.4 | 17.1 ± 2.1 | 2.02 ± 0.85 | 2.84 ± 0.33 | 98 ± 3 |
| Oral | 100 | 65.0 ± 2.6* , ** | 23.4 ± 1.6* , ** | 3.07 ± 0.82 | 3.26 ± 0.24 | 96 ± 1 |
| Oral | 4 × 100 | 71.8 ± 2.1 | 17.4 ± 0.7 | 5.12 ± 1.60 | 2.18 ± 0.44 | 95 ± 1 |
↵1-a Data expressed as a percentage of the administered dose (mean ± S.E.); n = 6 for urine and feces andn = 3 for exhaled radioactivity and total recovery.
∗, values significantly different from those of the group treated i.v. with 1 mg/kg, (p < .05).
∗∗, values significantly different from those of the group treated orally with 1 mg/kg, (p < .05).