Table 1

The in vitro rates of formation (picomoles per minute per milligram of microsomal protein) of metabolites by characterized human hepatic microsomes in incubations with 25 or 100 μM NVP

Microsomes^1-a	NVP Metabolite
	2-HydroxyNVP		3-HydroxyNVP		8-HydroxyNVP		12-HydroxyNVP
	25 μM	100 μM	25 μM	100 μM	25 μM	100 μM	25 μM	100 μM
2	2.99	16.23	0.46	2.74	0.09	1.79	1.71	9.24
3	0.32	2.01	0.13	1.09	ND	0.22	0.37	1.62
5	0.17	1.95	0.30	0.74	ND	0.24	0.38	1.78
6	4.15	22.66	2.50	7.09	0.45	3.06	2.71	13.59
7	0.66	3.88	0.11	1.34	ND	0.53	0.86	3.61
9	0.69	2.99	1.12	2.79	0.22	0.65	0.56	2.23
10	0.47	1.33	ND	0.35	ND	0.17	0.44	1.73
11	2.78	10.60	3.69	9.03	0.43	2.75	1.93	7.61
12	0.92	1.69	0.16	0.77	ND	0.25	0.33	1.45
13	1.57	5.37	0.45	0.98	0.14	0.59	0.90	3.46
Mean ± S.D.^1-b	1.47 ± 1.37	6.87 ± 7.32	0.99 ± 1.27	2.69 ± 2.98	0.26 ± 0.17	1.03 ± 1.10	1.02 ± 0.82	4.63 ± 4.14

ND = Not detected
↵1-a Microsome identification number provided by Human Biologics, Inc. (Phoenix, AZ).
↵1-b n = 10, except for 3-hydroxyNVP (25 μM) where n = 9 and 8-hydroxyNVP (25 μM) wheren = 5.