Dose Appearing in | ||||
---|---|---|---|---|
2 mg/cm2 | 20 mg/cm2 | |||
Mice | Rats | Mice | Rats | |
Absorbed | % | |||
Urine | 3.87 ± 1.32 | 4.85 ± 1.16 | 0.55 ± 0.05 | 0.46 ± 0.03 |
Feces | 2.40 ± 0.84 | 0.41 ± 0.08 | 0.36 ± 0.07 | 0.05 ± 0.01 |
Volatile radioactivity | 0.48 ± 0.26 | 0.36 ± 0.09 | 0.09 ± 0.01 | 0.08 ± 0.01 |
Dose site | 0.28 ± 0.05 | 0.70 ± 0.24 | 0.19 ± 0.17 | 0.17 ± 0.19 |
Total | 7.04 ± 1.30 | 6.32 ± 1.46 | 1.19 ± 0.23 | 0.77 ± 0.19 |
Unabsorbed | 79.4 ± 2.2 | 79.1 ± 6.7 | 63.3 ± 6.2 | 89.6 ± 5.3 |
Total recovery | 86.4 ± 2.8 | 85.5 ± 7.9 | 64.5 ± 6.3 | 90.3 ± 5.0 |
↵5-a 72-h dermal exposure