Table 4

Dynamic parameters of furosemide injected (2.5 mg/kg) to conscious rabbits, control rabbits, and rabbits with moderate hypoalbuminemia in absence or in presence of warfarin (5 mg/kg)

	Control (n = 4)	Hypoalbuminemia (n= 4)	Hypoalbuminemia + Warfarin (n = 4)
Plasma albumin (g/l)	31.5 ± 0.5	24.5 ± 1.3^4-a	24.3 ± 1.1^4-a
GFR (ml·min⁻¹·kg⁻¹)	5.1 ± 0.6	4.8 ± 0.5	4.6 ± 0.6
Unbound drug (%)	1.2 ± 0.1	5.5 ± 0.5^4-a	9.7 ± 1.4^4-b
Urinary recovery (%)	48.8 ± 3.0	40.0 ± 2.3^4-a	31.4 ± 2.1^4-b
Sodium excretion (mmol/h)	18.3 ± 1.9	14.5 ± 0.4^4-a	9.7 ± 0.1^4-b
Urinary volume (ml/h)	141 ± 8	111 ± 1^4-a	90 ± 4^4-b

Values are means ± S.E.
↵4-a p < .05 compared with control rabbits.
↵4-b p < .05 compared with control and hypoalbuminemic rabbits.