Table 1

Distribution of in vitro metabolites of ABT-378 in male mouse, rat, dog, monkey, and human liver microsomal incubations

Matrix	Rate of Disappearance of ABT-378 (nmol·mg⁻¹·min⁻¹)	% of Total Sample Radioactivity after a 30-min Incubation
Matrix	Rate of Disappearance of ABT-378 (nmol·mg⁻¹·min⁻¹)	ABT-378	M-1	M-2	M-3	M-4	M-5	M-6	M-7	M-8	M-9	M-10	M-11	M-12	Other
Mouse	−3.54	42.09	2.82	6.83	7.31	25.70	1.98	1.55	2.70	0.90	ND	0.66	1.47	2.34	4.31
Rat	−3.85	41.25	3.61	5.19	9.88	30.80	1.75	1.70	1.62	0.95	0.61	ND^1-a	0.95	0.55	1.75
Dog	−2.39	59.00	5.69	0.89	7.50	17.41	0.51	0.89	1.30	0.36	0.51	0.97	0.71	0.48	5.26
Monkey	−9.80	14.28	13.05	1.44	13.20	33.52	2.42	0.69	1.19	0.33	2.07	3.26	7.38	1.22	11.28
Human	−2.72	60.48	4.62	1.85	5.39	18.23	0.76	0.81	0.67	ND^1-a	1.52	1.05	1.79	2.14	0.69
HHS^1-b	−8.04^1-c	55.23	5.44	1.42	4.90	19.06	0.73	1.01	1.00	2.16	2.36	1.54	1.16	2.32	1.66
HLS^1-d	−1.06^1-e	74.54	0.25	ND^1-a	2.42	5.25	ND^1-a	ND^1-a	ND^1-a	ND^1-a	ND^1-a	ND^1-a	2.45	ND^1-a	15.33

ND, not detected; HHS, human hepatocytes; HLS, human liver slices. ABT-378 concentration was 25 μM (microsomes), 3 μM (liver slices) and 5 μM (hepatocytes).
↵1-a Small amounts of these metabolites were detected at later time points.
↵1-b Two-hour incubation with human hepatocytes.
↵1-c Pmol per million hepatocytes per minute.
↵1-d Six-hour incubation with human liver slices.
↵1-e Pmol per liver slice per minute.