Effect of various dihydroquinones on imipramine N-oxide reduction by rat liver cytosol
| Dihydroquinone | Imipramine Formed4-anmol/30 min/mg protein |
|---|---|
| None | 0.3 ± 0.1 |
| 1,4-Dihydroxybenzene | 1.1 ± 0.2 |
| Tetrahydroxy-p-benzoquinone | 3.1 ± 0.2 |
| 1,2-Dihydroxynaphthalene | 2.5 ± 0.3 |
| 1,3-Dihydroxynaphthalene | 2.2 ± 0.1 |
| 1,4-Dihydroxynaphthalene | 17.6 ± 3.9 |
| 1,5-Dihydroxynaphthalene | 2.0 ± 0.3 |
| 2,3-Dihydroxynaphthalene | 0.3 ± 0.1 |
| 1,4,9,10-Tetrahydroxyanthracene | 47.6 ± 2.4 |
| 1,4-Dihydroxy-9,10-anthraquinone | 71.3 ± 4.1 |
| Doxorubicin | 70.9 ± 3.2 |
Each value represents the mean ± S.D. of four experiments.
↵4-a The assay was carried out anaerobically using 0.2 ml of rat liver cytosol as described in Materials and Methods.