Kinetic parameters of bufuralol 1′-hydroxylation in expressed CYP2D isoforms
| CYP2D | Km | Vmax |
|---|---|---|
| μM | nmol/min/nmol P-450 | |
| 2D1 | 9.5 ± 0.8 | 2.9 ± 0.2 |
| 2D2 | 0.044 ± 0.004 | 6.3 ± 0.2 |
| 2D3 | 17 ± 1.2 | 8.0 ± 0.2 |
| 2D4 | 15 ± 0.7 | 8.5 ± 0.1 |
Each value represents the mean ± S.D. of three determinations.