Mean (S.D.) pharmacokinetic parameters for tizanidine (N = 15)
| Parameter | Tizanidine Alone | Tizanidine with Baclofen | % Change1-a |
|---|---|---|---|
| C max (ng/ml) | 2.51 (1.12) | 2.42 (1.03) | 9.7 (61.3) |
| T max(h) | 0.90 (0.27) | 1.10 (0.54) | 29.4 (66.4) |
| K el (h−1) | 0.60 (0.14) | 0.60 (0.11) | 8.4 (13.7) |
| t 1/2 (h) | 1.21 (0.26) | 1.18 (0.20) | −6.3 (13.5) |
| AUC(48-τ)(ng · h/ml) | 6.00 (3.75) | 5.72 (3.03) | 4.6 (46.5) |
| CLτ (ml/min) | 74.3 (39.4) | 58.9 (24.9) | 26.4 (151) |
| % Dose unchanged in urine | 0.75 (0.60) | 0.48 (0.27) | −13.8 (68.5) |
↵1-a % Change calculated as: {100 · (Parametertizanidine + baclofen − Parametertizanidine alone/Parametertizanidine alone)}.