Parameter | Tizanidine Alone | Tizanidine with Baclofen |
---|---|---|
Metabolite 3 | ||
C max(ng/ml) | 11.6 (2.36) | 13.4 (4.68) |
T max(h) | 1.3 (0.50) | 1.7 (0.80) |
K el(h−1) | 0.14 (0.04) | 0.13 (0.04) |
t 1/2 (h) | 5.37 (1.27) | 6.29 (2.95) |
AUC48-τ) (ng · h/ml) | 57.0 (16.4) | 58.9 (18.0) |
CLr (ml/min) | 13.6 (5.61) | 12.1 (4.17) |
Metabolite 4 | ||
C max(ng/ml) | 3.48 (1.34) | 3.53 (1.84) |
T max(h) | 1.5 (0.47) | 1.7 (0.86) |
K el(h−1) | 0.13 (0.06) | 0.14 (0.05) |
t 1/2 (h) | 6.96 (4.07) | 5.74 (2.74) |
AUC(48-τ) (ng · h/ml) | 17.0 (5.13) | 16.2 (5.55) |
CLr (ml/min) | 376 (134) | 466 (154) |