Table 1

Kinetic parameters for N-deacetylation of eprinomectin by rat liver microsomes

Liver MicrosomesKMVmax
μM nmol/mg/min
Male53  ± 50.8  ± 0.0
Female70  ± 165.0  ± 0.6
Male treated with PB90  ± 162.8  ± 0.3
Female treated with PB102  ± 255.7  ± 0.8
  • Incubations were performed with 0.5 mg/ml microsomal protein for 30 min at an eprinomectin concentration ranging from 8 μM to 100 μM. Results are means ± S.D.