Apparent kinetic parameters of NB-506 glucuronidation in mouse, rat, dog and human liver microsomes
| Liver Microsomes | Apparent Km | ApparentVmax | ApparentVmax/Km |
|---|---|---|---|
| μM | pmol/min/mg | μl/min/mg | |
| Mouse | 6.6 ± 0.3 | 40.6 ± 6.4 | 6.1 ± 0.7 |
| 159.1 ± 8.8 | 168.9 ± 15.1 | 1.1 ± 0.1 | |
| Rat | 5.8 ± 0.6 | 52.4 ± 6.6 | 9.1 ± 0.5 |
| Human | 75.1 ± 1.5 | 641.7 ± 298 | 8.5 ± 3.8 |
Each value represents the mean ± S.D. of three experiments. Glucuronidation of NB-506 was not observed in dog liver microsomes.