Mean (± S.D.) pharmacokinetic parameters of 2-AP after 1-min i.v. infusion of the drug, 10, 20, 50, and 100 mg/kg body weight, to rats
| Parameters | Body Weight | |||
|---|---|---|---|---|
| 10 mg/kg (N= 8) | 20 mg/kg (N = 9) | 50 mg/kg (N = 9) | 100 mg/kg (N = 6) | |
| Terminal half-life (min) | (211 ± 51.1)1-a | (192 ± 27.2) | 540 ± 116 | 569 ± 105 |
| AUC (μg min/ml) | 222 ± 45.2 | 409 ± 68.6 | 1100 ± 171 | 2190 ± 345 |
| MRT (min) | (50.4 ± 8.80) | (63.8 ± 16.2) | 102 ± 17.0 | 129 ± 5.20 |
| CL(ml/min/kg body weight) | 46.0 ± 9.57 | 48.9 ± 9.17 | 45.6 ± 7.01 | 45.7 ± 7.28 |
| V SS (ml/kg body weight) | (2320 ± 869) | (2880 ± 1360) | 4580 ± 620 | 5890 ± 1010 |
| Ae 0–24 h (% of dose) | 0.0673 ± 0.0516 | 0.526 ± 0.359 | 0.345 ± 0.0790 | 0.0926 ± 0.0544 |
↵1-a The numbers in parentheses represent pharmacokinetic parameters of 2-AP at the doses of 10 and 20 mg/kg body weight. Because the detection of plasma concentrations of 2-AP at 10 and 20 mg/kg body weight was shorter than those at 50 and 100 mg/kg body weight, these data were not included in statistical analysis.