Parameters | Body Weight | ||
---|---|---|---|
10 mg/kg (N= 15) | 50 mg/kg (N = 12) | 100 mg/kg (N = 13) | |
Terminal half-life (min) | (23.3 ± 4.90)2-b | 103 ± 20.3 | 92.5 ± 36.5 |
AUC2-a (μg min/ml) | 43.5 ± 23.2 | 624 ± 126 | 2050 ± 561 |
Ae 0–24 h (% of oral dose) | 0.0306 ± 0.0300 | 0.0492 ± 0.535 | 0.00263 ± 0.00260 |
F(%) | 19.6 | 56.7 | 93.6 |
↵2-a Dose-normalized AUC values were significantly different (p < .01) among doses.
↵2-b The number in parentheses represents terminal half-life of 2-AP at the dose of 10 mg/kg body weight. Because the detection of plasma concentrations of 2-AP at 10 mg/kg body weight was shorter than those at 50 and 100 mg/kg body weight, the value was not included in statistical analysis.