Ewe | AUC | EH | Fraction of i.v. Dose Metabolized in Liver (fH) | |||
---|---|---|---|---|---|---|
Parent (i.v.) | Parent (p.v.) | Metabolite (i.v.) | Metabolite (p.v.) | |||
ng · min/ml | ||||||
11581-a | 20,437.5 | 1,952.8 | 73,888.5 | 146,681.7 | 0.904 | 0.504 |
1154 | 14,728.5 | 1,411.5 | 6,811.4 | 37,415.4 | 0.904 | 0.182 |
1391-a | 14,140.9 | 595.3 | 11,518.8 | 26,096.7 | 0.958 | 0.441 |
1021-a | 9,812.6 | 437.8 | 16,360.9 | 60,500.2 | 0.955 | 0.270 |
989 | 7,311.1 | 76.6 | 12,513.7 | 54,520.1 | 0.990 | 0.230 |
Mean ± S.D. | 13,286.1 ± 5,042.8 | 894.8 ± 767.21-b | 24,218.7 ± 27,973.8 | 65,042.8 ± 47,634.91-c | 0.942 ± 0.037 | 0.325 ± 0.140 |
↵1-a In these ewes, [2H10]DPHM was given via the p.v. route and DPHM via the femoral venous route. In the other animals, the route of administration for the two forms of drug was reversed.
↵1-b Significantly lower than the parent drug AUC after i.v. administration (p < .005).
↵1-c Significantly larger than metabolite AUC after i.v. administration of the drug (p < .01).