Parameter (dimension) | 0.1 mg/kg | 1.0 mg/kg | 10 mg/kg |
---|---|---|---|
A (μg/g) | 0.0627 | 1.4098 | 18.9099 |
α (s−1) | 0.0102 | 0.0301 | 0.0268 |
B (μg/g) | 0.0476 | 0.6059 | 8.3537 |
β (s−1) | 0.0019 | 0.0036 | 0.0011 |
kelim(s−1) | 0.0036 | 0.0094 | 0.0032 |
kelim T 1/2 (s) | 194 | 74 | 218 |
AUC (μg/g × s) | 31 | 215 | 8580 |
Varea(ml/kg) | 1671 | 1288 | 1098 |
Summary of pharmacokinetic parameter estimates derived from nonlinear least squares fitting (PKAnalyst, MicroMath Scientific Software, Salt Lake City, UT, 1995) of arterial blood total HQ concentration after intratracheal administration of [14C]HQ at 0.1, 1.0, and 10 mg/kg in male Sprague-Dawley rats. The form of the equation is Ct = Ae−αt + Be−βt