Table 1

Pharmacokinetic analysis of total HQ concentrations in blood after intratracheal dosing

Parameter (dimension)0.1 mg/kg1.0 mg/kg10 mg/kg
A (μg/g)0.06271.409818.9099
α (s−1)0.01020.03010.0268
B (μg/g)0.04760.60598.3537
β (s−1)0.00190.00360.0011
kelim(s−1)0.00360.00940.0032
kelim T 1/2 (s)19474218
AUC (μg/g × s)312158580
Varea(ml/kg)167112881098

Summary of pharmacokinetic parameter estimates derived from nonlinear least squares fitting (PKAnalyst, MicroMath Scientific Software, Salt Lake City, UT, 1995) of arterial blood total HQ concentration after intratracheal administration of [14C]HQ at 0.1, 1.0, and 10 mg/kg in male Sprague-Dawley rats. The form of the equation is Ct = Ae−αt + Be−βt