Influence of CsA on [14C]aminopyrine metabolism
| Group | Time in Relation to 2/3 Partial Hepatectomy | ||
|---|---|---|---|
| Pre | 24h Post | 48h Post | |
| % dose exhaled as14CO2 | |||
| Control | 24.7 ± 0.3 | 17.9 ± 0.5*** | 18.6 ± 1.4** |
| (100%) | (68%) | (71%) | |
| CsA | 24.5 ± 0.8 | 18.2 ± 1.1* | 18.5 ± 1.6* |
| (100%) | (71%) | (73%) | |
Values represent the cumulative 14CO2exhaled during the 2-h collection period as % of the dose injected (or in parenthesis, normalized to 100% for the value observed prior to surgery). n = 4 animals/group for each time period studied. Statistically significant differences between group means were analyzed by two-way analysis of variance. Effect of treatment, N.S.; interaction with time: N.S. Effect of time: Control: p< .0002; CsA p < .008. Individual posthoc tests between pre and post PHx within the control or CsA group respectively were performed according to Bonferroni-Dunn: * p < .02; ** p < .003; *** p < .0003.