Influence of CsA on [14C]caffeine metabolism
| Group | Time in Relation to 2/3 Partial Hepatectomy | ||||
|---|---|---|---|---|---|
| Pre | 24h Post | 48h Post | 72h Post | 96h Post | |
| % dose exhaled14CO2 | |||||
| Control | 5.7 ± 0.5 | 2.3 ± 0.3* | 4.0 ± 0.4 | 8.9 ± 0.5** | 9.6 ± 0.9*** |
| (100%) | (40%) | (70%) | (156%) | (168%) | |
| CsA | 5.1 ± 0.5 | 4.4 ± 0.8 | 5.6 ± 0.7 | 8.6 ± 0.5 | 7.7 ± 0.9 |
| (100%) | (86%) | (110%) | (169%) | (151%) | |
Values represent the cumulative 14CO2exhaled during the 2-h collection period as % of the dose injected (or in parenthesis, normalized to 100% for the value observed prior to surgery). n = 4 animals/group for each time period studied. Statistically significant differences between group means were analyzed by two-way analysis of variance. Effect of treatment: N.S. Interaction time/treatment: p < .02. Effect of time: Control: p < .0001; CsA p < .006. Individual posthoc tests between pre and post PHx within the control or CsA group respectively were performed according to Bonferroni-Dunn: * p < .003; ** p < .006; *** p < .0008.