Table 3

Influence of CsA on [¹⁴C]erythromycin metabolism

Group	Time in Relation to 2/3 Partial Hepatectomy
Group	Pre	24h Post	48h Post	72h Post	96h Post
	% dose exhaled¹⁴CO₂
Control	12.2 ± 0.5	7.5 ± 0.6^***	6.6 ± 0.4^***	9.8 ± 0.9	9.1 ± 0.7
	(100%)	(61%)	(54%)	(80%)	(75%)
CsA	11.3 ± 0.7	8.0 ± 0.7^*	7.3 ± 0.4^**	9.5 ± 0.6	9.1 ± 0.7
	(100%)	(71%)	(65%)	(84%)	(81%)

Values represent the cumulative ¹⁴CO₂exhaled during the 2-h collection period as % of the dose injected (or in parenthesis, normalized to 100% for the value observed prior to surgery). n = 6 animals/group for each time period studied. Statistically significant differences between group means were analyzed by two-way analysis of variance. Effect of treatment: N.S. Interaction time/treatment: N.S. Effect of time: Control:p < .0001; CsA p < .003. Individual posthoc tests between pre and post PHx within the control or CsA group respectively were performed according to Bonferroni-Dunn: * p < .02; ** p < .003; *** p < .0002.