GA and weight-corrected estimates of total (CLmm and CLff), placental (CLmf and CLfm), and non-placental (CLmo and CLfo) DPHM clearances in the mother and the fetus, respectively, obtained using a two-compartment model of the maternal-fetal unit
| Ewe No. | GA (days) | Clearance Parameter | ||||||
|---|---|---|---|---|---|---|---|---|
| ml/min/kg | ||||||||
| Material Experiment | Fetal Experiment | CLmm1-a | CLmfb | CLmo1-a | CLffb | CLfmb | CLfob | |
| E1225A | 135 | 129 | 45.5 | 7.6 | 45.2 | 452.6 | 337.5 | 115.1 |
| E2174 | 140 | 135 | 24.6 | 44.9 | 23.5 | 317.2 | 129.7 | 187.5 |
| E303Y | 124 | 131 | 57.6 | 52.6 | 55.1 | 285.4 | 152.4 | 133.0 |
| E4227 | 131 | 126 | 31.9 | 31.2 | 30.6 | 145.5 | 91.5 | 53.9 |
| E4230 | 131 | 126 | 43.7 | 125.1 | 38.2 | 267.4 | 175.3 | 92.1 |
| Mean ± S.D. | 132.2 ± 5.9 | 129.4 ± 3.8 | 40.7 ± 12.8 | 52.3 ± 44.1 | 38.5 ± 12.3 | 293.6 ± 110.1* | 177.3 ± 94.7* | 116.3 ± 49.6* |
↵1-a clearance values are in ml/min/kg maternal weight;b clearance values are in ml/min/kg fetal weight; * significantly higher compared to the corresponding maternal value (p < .05).