Table 2

Arterial plasma AUC ratios of parent drug, preformed metabolite, andin vivo formed metabolite in the mother and the fetus

Ratio	Ewe No.		Mean ± S.D.
Ratio	1225A	2174	Mean ± S.D.	303Y	4227	4230
Maternal Administration
	0.06	0.41	0.63	0.52	0.43	0.41 ± 0.21
	3.78	2.08	3.83	2.85	2.30	2.97 ± 0.82
	0.43	0.35	0.98	0.25	3.66	1.13 ± 1.44
	67.2	4.6	18.3	3.0	14.4	21.5 ± 26.4
Fetal Administration
	0.02	0.02	0.01	0.01	0.05	0.02 ± 0.02
	0.07	0.08	0.15	0.06	0.87	0.25 ± 0.35
	1.10	0.79	1.22	0.74	9.61	2.69 ± 3.87
	4.11	1.49	2.86	1.39	1.72	2.32 ± 1.16