Maternal |
DPHM (or [2H10]-DPHM) | CLr
4-a
| 0.07 | 0.03 | 0.13 | 0.01 | 0.15 | 0.08 ± 0.06 |
| % dose excreted in maternal urine | 0.14 | 0.11 | 0.22 | 0.09 | 0.38 | 0.19 ± 0.12 |
Preformed DPMA Metabolite | CLr
4-a
| 0.79 | 0.36 | 0.37 | 0.46 | 0.48 | 0.49 ± 0.17 |
| % dose excreted in maternal urine | 91.4 | 83.5 | 79.0 | 94.7 | 91.5 | 88.0 ± 6.5 |
In vivo Formed DPMA Metabolite | CLr
4-a
| 0.86 | 0.43 | 0.51 | 0.35 | 0.48 | 0.53 ± 0.19 |
| Amount excreted in maternal urine (as % of parent drug dose) | 0.72 | 0.64 | 0.93 | 0.80 | 4.92 | 1.60 ± 1.86 |
Fetal |
DPHM (or [2H10]-DPHM) | CLr
4-a
| 1.00 | N/A4-b
| 0.20 | 0.13 | N/A4-b
| 0.44 ± 0.49 |
| % dose excreted in fetal urine | 0.22 | N/A4-b
| 0.07 | 0.10 | N/A4-b
| 0.13 ± 0.08 |
Preformed DPMA Metabolite | CLr
4-a
| 0.005 | N/A4-b
| 0.002 | 0.014 | N/A4-b
| 0.007 ± 0.0064-150 |
| % dose excreted in fetal urine | 0.78 | N/A4-b
| 0.40 | 4.18 | N/A4-b
| 1.79 ± 2.08 |
| % dose excreted in maternal urine | 88.5 | 92.48 | 82.1 | 96.3 | 101.4 | 92.1 ± 7.4 |
In vivo Formed DPMA Metabolite | CLr
4-a
| 0.007 | N/A4-b
| 0.004 | 0.011 | N/A4-b
| 0.007 ± 0.0044-150 |
| Amount excreted in fetal urine (as % of parent drug dose) | 0.004 | N/A4-b
| 0.002 | 0.005 | N/A4-b
| 0.004 ± 0.002 |